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There is a considerable interest in the asymmetric production of chiral allylic alcohols, the main building blocks of many functional molecules. The asymmetric reduction of α,β‐unsaturated ketones is difficult with traditional chemical protocols in a regioselective and stereoselective manner. In this study, the reductive capacity of whole cell of Leuconostoc mesenteroides N6, Weissella paramesenteroides...
In this work, enantioseparation of four chiral fluoroquinolones (FQs), namely, ofloxacin, gemifloxacin, lomefloxacin, and gatifloxacin, was achieved by capillary electrophoresis with sulfated‐β‐cyclodextrin (S‐β‐CD) as chiral selector. Factors affecting the enantiomeric resolution, such as the concentrations of S‐β‐CD, BGE pH conditions, and the buffer types and concentrations, were optimized and...
(1R,5S)‐2‐Methyl‐6,7‐benzomorphan has been synthesised from (R)‐(benzyloxy)(phenyl)acetaldehyde. On a 2‐mmol scale Bi (OTf)3 promoted Aza‐Prins reaction with N‐tosylhomoallylamine afforded an 88/12 mixture of 6‐oxa‐2‐azabicyclo[3.2.1]octanes. Major diastereoisomer was converted to enantiomerically pure (2S,4S)‐2‐benzyl‐1‐ methylpiperidin‐4‐ol via a high‐yielding sequence hydrogenolysis/N‐detosylation/N‐methylation...
Hybrid silica‐organic nanohelices are used to organize a large variety of nonchiral small organic molecules or inorganic anions to nanometer‐sized assemblies. Such chiral organization of achiral molecules induces chiroptical properties as detected by vibrational or electronic circular dichroism (CD), as well as from circularly polarized luminescence (CPL).
This short review focuses on enantiopure planar chiral [2.2]paracyclophanes (pCps), a fascinating class of molecules that possess an unusual three‐dimensional core and intriguing physicochemical properties. In the first part of the review, different synthetic strategies for preparing optically active pCps are described. Although classical resolution methods based on the synthesis and separation of...
The aim of the present study was to optimize a protocol for nuclear magnetic resonance (NMR) chiral discrimination to be used to determine the enantiomers ratio of agrochemicals. For this goal, the commercial agrochemicals fipronil and malathion were employed as active targets due the distinct physicochemical properties. We used the cyclodextrins to evaluate the chiral discrimination in aqueous media...
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